Intern, Large Molecule Bioanalytics

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.

Denali is seeking to hire a highly motivated summer intern who is interested in bioanalysis supporting drug development in the department of Translational Pharmacology and Bioanalysis (TP&B). As a member of Bioanalytical Sciences Group, the candidate will work closely with cross-functional teams to develop and implement innovative ligand binding assays for PK and immunogenicity (ADA) assessments of novel biotherapeutic candidates. The goals of this internship project include but are not limited to the evaluation and development of PK and ADA bioanalytical assays in rabbit biological matrices (such as serum/plasma, tissues, and CSF), Meso Scale Discovery (MSD) platform-based drug specific IgE assays, and generic MSD-based ADA assays; and implementation of the Gyrolab platform assays to conduct PK sample bioanalysis in support of exploratory PK/PD studies.

The position provides the opportunity to collaborate with scientists from different functions, including Discovery Biology, Development Sciences, and Translational Biomarkers, and allows gaining further knowledge of drug development. The intern will be co-supervised by scientists in Bioanalytical Group.